2014 Natural Pine Bark Extract 95% OPC,China Greensail price supplier

                                                  

                                                  100% Natural Pine Bark Extract

Latin name: Pinus maritime
Plant part used: Bark
Specification: 95% Proanthocyanidins UV-VIS, 95%, 75% Polyphenols UV
Testing methods: UV-VIS
CASNo: 29106-51-2
Main Function: Anti-oxidant, anti-cancer

Brief Introduction:

Synonyms--- Maritime Pine(Pinus maritima or Pinus pinaster)

Proanthocyanidin B4

Proanthocyanidin B4is a B type proanthocyanidin.Proanthocyanidin-B4 is a catechin-(4α→8)-epicatechin dimer. It is found in the litchi pericarp, in Grape Seeds, and, along with 4-cis-isomer of procyanidin B4, in beer.

Chemical Name:

CAS Number: 29106-51-2
Molecular Formula:C ₃₀ H ₂₆ O ₁₂

Mol. Wt.:578.52

The Maritime Pine (Pinus maritima or Pinus pinaster) is a pine native to the western Mediterranean region. It is a medium-size tree, reaching 20-35 m tall and with a trunk diameter of up to 1.2 m, exceptionally 1.8 m.The bark is orange-red, thick and deeply fissured at the base of the trunk, somewhat thinner in the upper crown.

It is widely planted for timber. It is also used as a source of flavonoids, catechins, proanthocyanidins, and phenolic acids; notably in the patented extract "pycnogenol". The patents for pycnogenol refer to Pinus maritima, an obsolete synonym for Pinus pinaster.

 

Benefits:

• Anti-oxidant activity

• Anticarcinogenic activity (Anti-cancer)

• Anti-imflamatory and antimicrobial

• Vasodilatory Properties

 

Mechanism:

OPCs possess antioxidant, antimutagenic, anticarcinogenic, anti-inflammatory, and antiviral properties.

Antioxidant

The potent antioxidative properties of OPCs account for their therapeutic benefit in disease states characterized by oxidative stress. OPCs also demonstrate potent, concentration-dependent, free radical scavenging ability. Studies in mice show OPCs inhibit chemically-induced lipid peroxidation, DNA fragmentation, and subsequent apoptosis in a dose-dependent manner in hepatic and brain tissue. Human studies also demonstrate an antioxidative mechanism as evidenced by decreased lipid peroxidation of LDL cholesterol and increased free-radical trapping capacity after consumption of red wine containing OPCs.

 

OPCs appear to have an affinity for vascular tissue and strongly inhibit several enzymes involved in degradation of collagen, elastin, and hyaluronic acid, the main structural components of the extravascular matrix.These effects are perhaps attributable to trapping reactive oxygen species and preventing oxidative injury to vascular endothelium. In vitro studies have also found OPCs increase resistance of cell membranes to injury and degradation.

 

Proanthocyanidins possess endothelium-dependent relaxing (EDR) activity in blood vessels by increasing nitric oxide production, and stimulate vascular endothelial growth factor, a signaling factor involved in initiation of wound healing. OPCs may also protect the microvasculature of the retina and increase visual acuity, possibly by increasing the rate of rhodopsin regeneration.

 

Anti-inflammatory

OPCs from pine bark decrease symptoms of chronic inflammation. In vitro studies demonstrate anti-inflammatory effects may be due to inhibition of peroxide generation by macrophages.In addition, animal studies demonstrate OPCs from grape seed significantly inhibit formation of proinflammatory cytokines, interleukin 1-beta, and tumor necrosis factor-alpha.

 

Antimutagenic/Anticarcinogenic

OPCs possess natural antimutagenic properties when exposed to certain strains of bacteria. Although the exact mechanism is not known, an in vitro study found OPCs exhibit selective cytotoxicity for certain cancerous cell lines, while remaining non-toxic to normal human gastric mucosal cells and macrophages.An in vitro study in a mouse skin tumor model demonstrated OPCs' inhibition of two markers of tumor promotion.

 

Safety:

Pine Bark Extract is safe.

 

Dosage:

•  The typical dose is 300-900mg per day (usually in 2-3 doses throughout the day).

 

Pine Bark Extract Features:

•  Produced with pure water only

•  High purity: over 95%

•  NO solvent - residual free

•  Pesticide-free

•  Red-brown in appearance

•  High solubility in water

•  High anti-bacteria, and longer shelf life

 

Certificate of Analysis:

Loss on Drying		≤5.0%, 5g / 105°C / 2hrs
Particle Size		100%Through 80 mesh
Ash		≤2.0%, 2g / 525°C / 2hrs
Solvent Residue		Eur.Pharm 2000, Gas Chromatography
Total Heavy Metals		≤10ppm, Atomic Absorption
Arsenic		≤2ppm, Atomic Absorption
Lead		≤1.0ppm, Atomic Absorption
Total Plate Count		≤1000cfu/g
Total Yeast & Mold		≤100cfu/g
E.Coli		Negative
Salmonella		Negative