Best Quality Natural Vine Tea Extract Powder/DMY 98%,China LLT price supplier

100% Natural Vine Tea Extract with Dihydromyricetin from GMP Manufacturer  

English name:  Vine tea extract powder dihydromyricetin.

Other names:  Ampelopsin, ampeloptin           
Chemical name:  (2R,3R)-3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-4-one
Botanical origin:  Ampolopsis grossedentata W.T.Wang. 
Part of the plant used:  Stems and Leaves

Specifications:  Dihydromyricetin ( DMY ) 50%, 80%, 90%, 98% (HPLC) 
CAS No. : 27200-12--0 
Molecular structure & weight:  C15H12O8, 320.25 
Extract solvents:  Ethanol & water 
Appearance:  Fine white crystalline powder for the 98% above, the low content powder is light greenish white.
Solubility:  easy soluble in hot water, hot ethanol and acetone, soluble in ethanol, methanol, slightly soluble acetic ether, insoluble in chloroform, petroleum ether.
Stability:  stable in heat, but when heated to 100°C above, it will be oxidized irreversibly. It is stable in acidity and neutral.  

 

Brief Introduction:

Our Dihydromyricetin is isolated from the Vine Tea. The Vine tea is made by the leaves of the plant-- Ampelopsis grossedentata (Hand-Mazz)W.T.wang. The Dihydromyricetin has the function of clearing the free radical in human body, antioxidation,  antithrombotic effect, anti-tumor, diminishing inflammation, protecting the liver.    
 

What is Dihydromyricetin?  

Dihydromyricetin (Ampelopsin (flavanol); Ampeloptin) is a natural antioxidant with good prospects. The physicochemical properties of dihydromyricetin (Ampelopsin (flavanol); Ampeloptin) were analyzed by ultraviolet–visible spectrometry, infrared spectrometry, scanning electron microscopy, differential scanning calorimetry, Xray diffractometry. The result showed that dihydromyricetin (Ampelopsin (flavanol); Ampeloptin) and Lecithin inthe complex were combined by non-covalent bond, did not form a new compound and the solubility of dihydromyricetin in n-octanol was significantly enhanced.   

Ampelopsis grossedentata is called Teng Cha in China, as a Chinese Herbal Medicine it has a glycol flavor, the nature is cool; it can alleviate fevers, drunkness, cure rheumatism, strengthen physique, diuresis, and many other functions.

 

Ampelopsis grossedentata contains rich flavones, amino acids, vitamins; Proteins and essential trace element.

 

The flavones are mainly dihydromyricetin, myricetin, quercetin, quercetin-5-O-²–D-glucoside, taxifolin, apiin.

Dihydromyricetin as a novel anti-alcohol intoxication medication

Alcohol use disorders (AUDs) constitute the most common form of substance abuse. The development of AUDs involves repeated alcohol use leading to tolerance, alcohol withdrawal syndrome, and physical and psychological dependence, with loss of ability to control excessive drinking. Currently there is no effective therapeutic agent for AUDs without major side effects. Dihydromyricetin (DHM; 1 mg/kg, i.p. injection), a flavonoid component of herbal medicines, counteracted acute alcohol (EtOH) intoxication, and also withdrawal signs in rats including tolerance, increased anxiety, and seizure susceptibility; DHM greatly reduced EtOH consumption in an intermittent voluntary EtOH intake paradigm in rats. GABA(A) receptors (GABA(A)Rs) are major targets of acute and chronic EtOH actions on the brain.

At the cellular levels, DHM (1 μM) antagonized both acute EtOH-induced potentiation of GABA(A)Rs and EtOH exposure/withdrawal-induced GABA(A)R plasticity, including alterations in responsiveness of extrasynaptic and postsynaptic GABA(A)Rs to acute EtOH and, most importantly, increases in GABA(A)R α4 subunit expression in hippocampus and cultured neurons.

 

DHM anti-alcohol effects on both behavior and CNS neurons were antagonized by flumazenil (10 mg/kg in vivo; 10 μM in vitro), the benzodiazepine (BZ) antagonist. DHM competitively inhibited BZ-site [(3)H]flunitrazepam binding (IC(50), 4.36 μM), suggesting DHM interaction with EtOH involves the BZ sites on GABA(A)Rs. In summary, we determined DHM anti-alcoholic effects on animal models and determined a major molecular target and cellular mechanism of DHM for counteracting alcohol intoxication and dependence. We demonstrated pharmacological properties of DHM consistent with those expected to underlie successful medical treatment of AUDs; therefore DHM is a therapeutic candidate.

 

 

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