【Introduction】: More than two centuries ago, Native Americans discovered that the root of the black cohosh plant (Cimicifuga racemosa) helped relieve menstrual cramps, and symptoms of menopause including hot flashes, irritability, mood swings, and sleep disturbances. Today, the roots of black cohosh are still often used for these purposes. In fact, the herb has been widely used for more than 40 years in Europe and is approved in for premenstrual discomfort, painful menstruation, and menopausal symptoms.