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The kola nut has a bitter flavor and contains caffeine. Kola Nuts are often used to treat whooping cough and asthma. The caffeine present acts as a bronchodilator, expanding the bronchial air passages.

Kola nuts are perhaps best known to Western culture as a flavouring ingredient and one of the sources of caffeine in cola and other similarly flavoured beverages, although the use of kola (or kola flavoring) in commercial cola drinks has become uncommon.

Kola nuts contain about 2 percent to 3.5 percent caffeine, are of bitter flavor, and are commonly used in cola soft drinks, such as Coca-Cola, Pepsi and Blue Sky. They have effects similar to other xanthine-containing plant products such as chocolate, tea, coffee, guarana and yerba mate. They have stimulant effects on the central nervous system and heart. Animal experiments indicate that kola nuts have analeptic and lipolytic (fat-burning) properties, and stimulate the secretion of gastric juices. Human studies show kola nuts have positive chronotropic and weak diuretic effects. In humans it enhances alertness and physical energy, elevates mood, increases tactile sensitivity and suppresses the appetite. Autonomic changes include increased body temperature, increased blood pressure and increased respiratory rate. Effects may last up to 6 hours after ingestion. In medicine the refined extract is used as a cardiac and central-nervous-system stimulant.

African Kola Nut is a stimulant.  It contains more caffeine than a Coffee Bean and is taken in the same way, as a caffeine stimulant, to prevent and fight fatigue.  In the past it was used by armies on the march, because the stimulating effects allowed for long distances to be traveled while carrying a minimum of food.  It has been said that the African Kola Nut possesses a physiological property of enabling persons ingesting it to undergo prolonged exertion without fatigue, undoubtedly due to its high caffeine content.

The caffeine content in African Kola Nut may also help to relieve migraine headaches.  Conventional wisdom has always asserted that all caffeine will cause headaches, but some modern research claims that judicious use of caffeine may actually ease migraines, and it is even included in several over-the-counter migraine preparations.  As a neuralgia treatment, African Kola Nut is also thought to relieve the pain of neuralgia (the severe, throbbing or stabbing pain along the course of a nerve).

African Kola Nut is also believed to be a fine "nervine" or nerve tonic that has a soothing and quieting influence on the nerves without numbing them.  In addition, the tonic effect stimulates and tones up the nervous system and imparts an overall feeling of healthy well-being. It has been used to alleviate nervous debility, temporary depression, despondency, weakness, nervous diarrhea, anxiety and lack of emotion.

African Kola Nut is said to be a cardiotonic that stimulates and strengthens a weak heart.

In traditional herbal medicine and lore, African Kola Nut was taken before a meal to improve digestion, and it has been reported that in Africa, its use exercised a favorable influence upon the digestive organs - particularly the liver - and most notably in the non-native populations who appeared to escape the constitutional changes due to affections of that organ. Further tradition stated that African Kola Nut rendered the most foul and putrid waters clean, made tainted meat edible; and when taken internally, helped prevent dysentery.