| ≥1 piece |
Latin name: Polygonum cuspidatum sieb.et Zuec
Part used: Rhizome
Appearance: Orange or redish brown powder
Test Method:HPLC
Part of the Plant Used: Root & Rhizome of Polygonum cuspidatum Sieb. et Zucc.
Extract Method:Alcohol Applicable field:Medicine Assay:10%--99%
Active material: Resveratrol Molecular Formula :C14H12O3 Molecular Weight:228.24 Melting point: 253oC-255oC Solubility: soluble in diethyl ether, Chloroform, Etheyl alcohol, acetone Packing: Double-deck plastic bag, pack with aluminium foil paper outside
Shelf Life : 2 years under well Storage situation and stored away from direct sun light.
What is the Giant Knotweed Extract?
Giant knotweed is an east Asian species (Polygonum cuspidatum), belonging to the Polygonaceae family. Documented uses in traditional Chinese medicine date to the first century BC, and contemporary medical uses supported by clinical results include acute microbial infections or viral hepatitis, chemo- or radiation-induced leukocytopenia, atherosclerosis, and hyperlipidemia.
Giant knotweed extract has exhibited antitussive, antihistaminic, hypotensive, vasodilating, cytotoxic, and antioxidant properties, among others. Giant knotweed extract is also a concentrated source of resveratrol, an antioxidant phenol produced in response to fungi. Resveratrol has also shown antimutagenic activity in bioassays conducted on bacteria in vitro. And, in a recent investigation conducted in vivo and in vitro, resveratrol displayed chemopreventive effects at three critical stages of carcinogenesis. Specifically, resveratrol was found to 1) induce phase II drug metabolizing enzymes; 2) mediate anti-inflammatory effects and inhibit cyclooxygenase and hydro-peroxidase (antipromotion); and 3) induce human promyelocytic leukemia cell diferentiation. Resveratrol was also found to inhibit the development of preneoplastic lesions in vitro and tumorigenesis in vivo. Very recently, it was reported that Giant knotweed extract is one of the best active-oxygen scavengers for the prevention of skin aging induced by UV-irradiation and free radical. Experiments conducted in vivo indicate that resveratrol is a potent vasodilator and inhibitor of platelet aggregation. Recent work in dogs and humans indicate that other concentrated sources of resveratrol eliminate cyclic blood-flow reductions caused by platelet-mediated thrombosis.
Where will be Giant Knotweed Extract used to?
Anti-lipid oxidation
Heart disease prevention
Anti-carcinogen
Anti-platelet aggregation
Smoothes blood vessels
Decreases blood lipid
Application:
1. Promoting blood circulation and relieving pain in menopause, Arthralgia due to wind-cold-dampness and traumatic injury;
2. Clearing away pathogenic heat and dampness in moist heat ICT and leukorrhagia;
3. Clearing away heat and expelling toxin in scald, sore and carbuncle as well as snakebite.
1. Stopping coughing and resolving phlegm in curing the lung heat.
2. Clearing away heat and loosing the bowels in caring the constipation resulting from heat.
Giant Knotweed
Parts UsedáoPolygonum cuspidatum is native to eastern Asia and widely distributed in China. Polygonum cuspidatum have been used in traditional Japanese and Chinese medicine to treat a wide range of afflictions, including fungal diseases, various skin inflammations, cardiovascular diseases and liver diseases.
Function
1 Antipyretic and Analgesic Activity
Resveratrol is therapeutic in several different ways. It appears to have antipyretic and analgesic activities, as studied in intact mice and rats (Lin & Hsu, 1987). The extracts appeared to confer protection of the gastric membrane against stress ulcers by slight inhibition of gastric secretion without effect on blood pressure.
2 Anti-cancer and Anti-mutagen Activity
Resveratrol exhibits cancer chemo-preventive activity by acting as an antioxidant, an antimutagen, and an anti-inflammatory agent. It also induces human promyelocytic leukemia cell differentiation (anti-progression activity) and inhibits the development of preneoplastic lesions in mouse mammary glands. Resveratrol can also inhibit protein-tyrosine kinase, which catalyzes the phosphorylation of tyrosine. This kinase is involved in signal transduction in the cytoplasm of a cell involved in the regulation of mitogenesis. The inhibition of protein-tyrosine kinase by resveratrol is possibly antimutagenic by detering the kinases function.
3 Prevention of Heart and Liver Damage
Resveratrol inhibits the deposition of triglycerides and cholesterol in the liver of mice. It also reduces the elevation of aspartate transaminase and alanine transaminase by inhibiting lipid peroxidation in the livers of rats. Analysis of these two enzymes in blood serum gives good diagnostic information for heart and liver damage.
4 Antithrombotic Activity
Resveratrol inhibits lipoxygenase production, which are enzymes found in leukocytes, the heart, brain, lung, and spleen. Thus resveratrol prevents the formation of blood clots within blood vessels. It also inhibits platelet aggregation after treatment with clonidine, an antihypertensive drug.
5 Immune System Improvement in Wound Healing
Resveratrol also promotes healing of burns by enhancing the immune system. Luo (1993) studied the effects of resveratrol on the restoration of suppressed cell-mediated, humoral, and non-specific immune functions in scald mice. Administration of resveratrol provided immuno-modulating effects in a dose-dependent fashion. Lou, et al (1995) showed that resveratrol restored impaired functions, such as response to antigen signal, the proliferative capacity, interleukin II production, and antibody production ability by lymphocytes, in different degrees in severely burned mice. Severely burned animals survived longer while their neutrophil levels and neutrophilic adhesive rates remained near normal due to treatment with resveratrol administered.