| ≥1 piece |
Avantage:
- Ture Manufacturer with 3000 Square Meters workshop
- Non-irradiation, Non-GMO,Allergen Free Products
- Strictly testing system before shipping
-ISO9001:2000 Certificate
-Free samples available
Product Description:
Product name: Indole-3-carbinol ( I3C )
Synonym: 3-Hydroxymethylindole , 3-Indolemethanol; Indole-3-methanol
Appearance : White to slightly yellow crystal
SPECIFICATION: Min. 99%
CAS NO.: 700-06-1
INECS : 211-836-2
Molecular formula : C9H9NO
Molecular weight : 147.18
Melting point : 96-99 ºC
Boiling point : 360.6oC at 760 mmHg
Storage : Store in under -5 °C .Do not store in normal temperatur , k eep away from acidity substance.
Shelf life: 1 years when properly stored.
Packing: Cardboard drum (25kg/drum), double plastic bag of foodstuff inside.
Functions:
- Indole-3-carbinol and its main metabolite diindoylmethane modulates several nuclear transcription factors resulting in a variety of biological and biochemical effects. Indole-3-carbinol works as a strong antioxidant , thereby protecting the DNA and other cell structures.
- Chemopreventive : Indole-3-carbinol has chemopreventive activity and stimulates the production of detoxifying Enzymes. The phytochemical protects against carcinogenic effect of pesticides and other toxins.
- Anticancer : The anticancer effects of indole-3-carbinol and its metabolite diindoylmethane are the result of specific activities: inducing enzymes that metabolize carcinogens, enhancing DNA repair, inducing G1 cell cycle arrest and apoptosis. Indole-3-carbinol blocks estrogen receptor sites on the membranes of breast and other cells, thereby reducing the risk of cervical and breast cancer . Indole-3-carbinol increases the ratio of 2-hydroxyestrone to 16 alpha-hydroxyestrone and inhibits the 4-hydroxylation of estradiol. This is a favourable action of indole-3-carbinol because 16 alpha-hydroxyestrone and 4-hydroxyestrone have carcinogenic action. The estrogen metabolite 2-hydroxyestrone has protective against several types of cancer. Studies with animals have demonstrated that indole-3-carbinol reduced the carcinogenic affects of aflatoxins. The influence of indole-3-carbinol on the development of prostate cancer is less clear. Most studies report protective effects but a few studies indicate that indole-3-carbinol may promote prostate cancer formation. Treatment of skin cancer cells with ultraviolet-B results in the apoptosis of their apoptosis, a favorable effect that seems to be stimulated by indole-3-carbinol. Some studies also show a beneficial effect on the treatment of skin cancer.
- Heart health : A few studies demonstrate the beneficial effects of indole-3-carbinol on lipid synthesis and platelet aggregation, suggesting that this phytochemical could help to improve heart health .
Application s : Used as Nutraceuticals, or Pharmaceutical intermediate for medicines .
Sources:
I ndole-3-carbinol (C9H9NO) is produced by the breakdown of the glucosinolate glucobrassicin, which can be found at relatively high levels in cruciferous vegetables such as broccoli, cabbage, cauliflower, brussels sprouts, collard greens and kale. indole-3-carbinol is also available in a dietary supplement. indole-3-carbinol is the subject of on-going Biomedical research into its possible anticarcinogenic, antioxidant, and antiatherogenic effects.
Indole-3-carbinol can shift estrogen metabolism towards less estrogenic metabolites. indole-3-carbinol has an effect on human papilloma virus infected cells in both pediatrics and adult patients.
Relative products:
Product name Cas No.
Indole-3-Carbinol 700-06-1
3,3'-Diindolylmethane ( DIM ) 1968-05-4
2,3-Dimethylindole 91-55-4
3-Indolepropionic acid 830-96-6
Indole-3-carboxaldehyde 487-89-8
3-Indolebutyric acid 133-32-4
Indole-3-carboxylic acid 771-50-6
MAILTO SUNNY-SANG AT HOTMAIL DOT COM