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High quality and lowest price 100% natrual Scopolamine 99%:  scopolamine powder

 

Scopolamine powder

 

One kind of tropane alkaloids , which exists in Solanaceae plants, molecular formula is C17H21NO4. 1892 year E. Schmidt first separated from scopolamine . Similar effect with atropine , its dilation and inhibit glandular secretion stronger effects than atropine , a stimulant of the respiratory center , but significantly inhibited the cerebral cortex , in addition to the expansion of capillaries , improve microcirculation and anti- motion sickness seasick , etc. effect.

 

Chinese name : scopolamine
Chinese alias : 6 - methyl-3 - oxa - aza- tricyclo [ 3.3.1.02,4 ] nonane -7 - Alcohol (-)-alpha-( hydroxymethyl ) phenylacetate
Name : Scopolamine
MF : C17H21NO4 [2]
Density : 1.31
Description: tablet: Each tablet 0.2mg. Injection: Each 0.3mg (1ml); 0.5mg (1ml motion sickness tablets: Each tablet contains the product 0.2mg, phenobarbital sodium 30mg, atropine 0.15mg, due to turbulence caused ) . Effective motion sickness , each serving a ~ 2 , half an hour after the results . So Baoding (SCOPODERM TTs) each affixed with 1.5mg.

Scopolamine is a viscous syrupy liquid ; bitter and spicy ; Specific rotation [ α ] She -18 ° ( ethanol ) or -28 ° ( water ) ; soluble in alcohol, ether, chloroform , acetone and water , slightly soluble in benzene and petroleum ether, the solubility in cold water still ; be inOrganic or organic acids with a variety of crystalline salts. In dilute alkali Yi racemization generate D, L- scopolamine , loss optically active . Reaction of mercury chloride and a white precipitate.

 

Scopolamine Yangjinhua as raw material extraction to obtain . China 's traditional Chinese medicine narcotic Yangjinhua preparations , from the 2nd century AD, the famous doctor Hua Tuo Mafeisan , the active ingredient is scopolamine .
Scopolamine in the pharmacological effects of belladonna alkaloids strongest , can be used to block the parasympathetic , also used as central nervous system depressants . It acts like atropine , but the role of a strong and relatively short. The general clinical use of its hydrobromide salt , can be used for analgesia , cough , asthma , motion sickness for effective , can also be used to control stiffness and tremor Parkinson 's disease . Effect of scopolamine and atropine similar to the dilation and inhibit glandular secretion stronger than atropine , a stimulant of the respiratory center , but significantly inhibited the cerebral cortex , in addition to the expansion of capillaries , improve microcirculation and anti- motion sickness seasick and so on. Clinical use of sedatives, before the administration of general anesthesia is used , motion sickness , tremor, paralysis, manic psychosis, organic phosphorus pesticide poisoning. As the product both excited breathing and calming effect on the brain cortex was therefore very severe encephalitis for rescue respiratory failure ( often accompanied by frequent violent convulsions ) are also effective.

 

Pharmacological effects

Antimuscarinics tertiary amine product . Its role generally similar to atropine, both on the central and peripheral effects . Atropine than the stronger effect of saliva secretion , slow down the heart rate is usually not accelerate the heart rate , especially in the use of small doses . Its central role and different atropine , can inhibit the cerebral cortex , resulting in lethargy and forgetfulness . Eye muscle and glandular secretion inhibition stronger than atropine . This product is a peripheral anticholinergic drugs , in addition to smooth muscle spasm , there are blocking the ganglion and nerve - muscle joint effect on the central role is weak. Atropine eye role and similar, mydriasis , paralysis of accommodation and atropine inhibit the secretion stronger than doubled , but the duration is short. In contrast with atropine excited brain , the product showed significant sedation. Scopolamine and atropine peripheral effects similar to its salivary , bronchial , and sweat glands stronger inhibition than atropine , mydriasis and paralysis of eye effect quickly than atropine , but the effect disappeared quickly, the heart, intestinal and bronchial smooth muscle the role of weak . It also has relieve spasm and the role of microcirculation . In general therapeutic doses significantly inhibited on the central . Larger doses can produce hypnotic effects. Large doses can produce more excitement, anxiety, hallucinations or delirium and other symptoms of central nervous system stimulation , but quickly got into the sleep state. Higher dose (0.08mg/kg intravenous injection ) is more pronounced cortical inhibition . When combined with chlorpromazine may soon produce paralysis . Scopolamine respiratory stimulant , anti- motion sickness and antiparkinsonian effect of atropine were low intensity .

Pharmacokinetics

The oral absorption from the gastrointestinal tract quickly . Almost completely metabolized in the liver , only a tiny fraction of the original drug in the urine. It can be through the blood - brain barrier and the placenta . Transdermal formulation of this product is also easy to absorb . Its t1 / 2 was 2.9h, volume of distribution 1.7L/kg. 0.5% solution of this product , eye , 20min produce maximum dilation effect , sustained 90min, 3 ~ 7 days back sight point level . Maximum cycloplegic effect produced in 40min and lasts about 90min, 72h gradually restored. After injection of scopolamine 0.5 ~ 1h, the plasma is about 0.5% of the total amount introduced , after reaching its peak concentration decreased rapidly , t1 / 2 for the 1.35h. Its distribution in the body to the brain , liver, lung is relatively high, in drug concentration after a few min to 30min gradually increased , 2 ~ 3h still maintain a certain concentration , the larger the role of the brain and long-lasting , the peak at about 2h , indicating it smoothly through the blood - brain barrier . Inject drugs , 30min total urinary excretion introduced volume reached 27.15%, 1h reached 49.5%, 2h reached 75.88%, 48h up to 92.8% .

Drug corresponding role

1 physostigmine , analeptic , belladonna poisoning reaction may be discharged , the application can be used as an antidote . 2 amphetamine and Cytospaz excitability have synergistic effects . 3 Torah oxazoline with a synergistic effect of scopolamine . 4 . Stability phenobarbital can antagonize Belladonna central stimulant, can be used to Belladonna poisoning treatment. 5 belladonna antipyretic and analgesic drugs can delay and reduce the absorption and reduced antipyretic effect . 6 Belladonna pressor drugs can reduce the antihypertensive effect. 7 belladonna drugs slows gastric emptying , increase the absorption of digitalis drugs , combined with the two drugs prone to cause long-term cardiac glycoside poisoning. 8 belladonna alkaloids alkaline hydrolysis can fail . 9 dilute hydrochloric acid and belladonna mixture incompatibility exists and pharmacodynamic antagonism , not while taking. 10 Copper sulfate can be used as oral belladonna poisoning emetic. 11 in combination with atropine treatment of organophosphorus pesticide poisoning, can play a synergistic role, but also increased adverse reactions , it should pay attention to adjust the dose. 12 in combination with anesthetics can reduce respiratory and saliva secretion, prevent aspiration pneumonia , prevent the occurrence of laryngeal edema and bronchospasm.

 

Dosage

1 . Prevention and control of motion sickness : 0.5h before departure oral 0.3mg, if necessary , every 6 hours 1 , 24h maximum of 3 times. Children 4 to 10 years old may be given 75 ~ 150μg,> 10 year-olds can give 150 ~ 300μg. This product can also be prevented by motion sickness transdermal preparations , such preparations can be affixed to the ear , can be used within 3 days 1mg. Plaster should be applied before departure 5 ~ 6h . Citie Cream can also be used for adult prevent nausea and vomiting after surgery . (2) The product can also be subcutaneous, intramuscular or intravenous administration : For vomiting , each may be given 0.3 ~ 0.6mg. Intravenous injection should be diluted with water for injection . 3 The goods 0.2 ~ 0.6mg often associated with opioid full alkali subcutaneous or intramuscular injection , administered as before anesthesia ( before induction of anesthesia 30 ~ 60min). 4 This product is 0.25% to 1% solution or ointment solution eye , can play the role of mydriasis and cycloplegia . It is more than atropine late onset , persistence time is shorter, but still amounted to 3 to 7 days. 5 bronchial asthma and asthmatic bronchitis : Each 0.3 ~ 0.5mg intravenously , if necessary, repeat after a few hours , a day after a times can be.

Indications

1 used before anesthesia administration , motion sickness , Parkinson's disease. (2) relieve muscle spasms ( especially gastrointestinal tract ) , and pupil dilation . 3 rescue organophosphate poisoning . 4 is mainly used in patients allergic to atropine , but also for mild iridocyclitis . For bronchial asthma and asthma-like bronchitis.

Contraindications

Banned from glaucoma , prostatic hypertrophy, myasthenia gravis, severe heart disease, organic pyloric stenosis, gastrointestinal obstruction disease , reflux esophagitis, ulcerative colitis or toxic megacolon patients . Poisoning cholinergic drugs were available to rescue and symptomatic treatment.

 

Precautions

1 caution in congestive heart failure , coronary heart disease , hypertension , tachycardia, hyperthyroidism, ileostomy or colostomy surgery, mild liver or kidney disease. (2) used with caution in infants , children and elderly patients . Breastfeeding is safe. 3 drug overdose and treatment: ( 1 ) physostigmine , analeptic , can be lifted belladonna poisoning reaction can be applied as an antidote . ( 2 ) stability and phenobarbital , may antagonize Belladonna central stimulant, can be used to Belladonna poisoning treatment. ( 3 ) sulfate 0.3 ~ 0.5g, dissolved in 100 ~ 250ml water , can be used as oral belladonna poisoning emetic. Should not use ipecac or apomorphine induce vomiting. (4) Other : For motion sickness , preventive medication effects, and diphenhydramine combination to increase efficacy . When administered to avoid eye caused by systemic absorption , may drip with your fingers on the pressure in the lacrimal sac 2 ~ 3min. Medication should be estimated anterior chamber depth, to avoid inducing angle-closure glaucoma. When used in ophthalmology , its toxicity incidence than other anticholinergic drugs is high. It is not appropriate as the drug of choice. During the administration to avoid driving or engaging in dangerous activities . 5 If an allergic reaction should be promptly discontinued . 6 injection to avoid the attention of nerves and blood vessels. If required repeated injections , injections should turn around , do not injected at the same site .

 

Adverse Reaction

1 Cardiovascular system : tachycardia is common adverse reactions, especially when a larger amount . There hypotension have been reported. (2) the central nervous system : high doses , can cause dizziness , restlessness, tremor , fatigue, and difficulty in movement . Administered through the skin can also cause drowsiness , restlessness, memory impairment , hallucinations and confusion. Children appear disorientation, irritability, confusion, hallucinations and tremors likely than adults. Cause a coma, high fever , convulsions have been reported. 3 Digestive System: dry mouth, constipation. 4 urinary / reproductive system : may cause dysuria and urinary retention , especially in elderly patients should pay attention to . 5 Eyes : Prolonged use can cause local irritation eye preparations , namely conjunctivitis, vascular congestion , edema, dermatitis and eczema . In addition, visual hallucinations may also occur . There dilation effect, can cause blurred vision and photophobia . Larger doses , can also occur ciliary body paralysis. Administered through the skin can occur dry eyes, redness or itching, can also lead to acute angle-closure glaucoma. Occasionally cause pupil sizes and esotropia . 6 Skin : Skin adhesives can cause skin rashes , erythema, contact dermatitis . 7 withdrawal symptoms : Some patients disabled scopolamine skin adhesives after withdrawal symptoms, including dizziness , nausea , vomiting , headaches and balance disorders . Medication over three days were , these withdrawal symptoms are more common. Occasionally cause psychosis after administration through the skin .

 

 

Packing &Storage Condition

 

Storage: Store in cool & dry place, Keep away from strong light and heat. 

Shelf life: 24Months when properly stored. 

Packing: 25/kg paper drum and two plastic-bags inside

 

 

Product Name: Scopolamine (51-34-3)

 

CBNumber:    CB9875364

 

Molecular Formula: C17H21NO4

 

Formula Weight:    303.35

 

CAS No.:       51-34-3

 

Manufacture Date: Oct. 16, 2013  Certificate Date: Oct. 18, 2013  Exp Date: Oct. 15, 2016

 

Item	Specification	Result	Method
Basic Product Information
Country of Origin	China	Conform	/
Scopolamine	>99--100%	99.78%	HPLC
Related substance	Total impurities<0.35%	0.12%	HPLC
	Unidentified impurity<0.2%	0.03%
	(-)-scopolamine hydrobromide≤0.1%	0.02%
	N-butyl Nonscopolamine bromide<0.2%	0.04%
	(-)-Scopolamine propylbromide<0.2%	0.06%
	(-)-scopolamine methylbromide<0.2%	0.08%
	Tropic acid<0.2%	0.07%
	Apo-N-Hyoscine butylbromide<0.2%	0.09%
Organoleptic Data
Appearance	Crystalline powder	Conform
Color	White	Conform	GB/T 5492-2008
Odor	Characteristic	Conform	GB/T 5492-2008
Taste	Characteristic	Conform	GB/T 5492-2008
Salmonella	Negative	Negative	FDA (BAM) Chapter 5, 8th Ed.

 

Batch No. CPC131016     Batch Quantity: 5kgs