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Macleaya cordata (Willd.)R.Br is a bloodroot which owns thousand year history of medicinal usage in China. 13 kinds of alkaloids and other compounds such as sanguinarine, toddaline, protopine, a-allocryptopine, bocconine, rhizoma coptidis alkali, berberine, samin alkali and protopine are in the root and aerial parts. Macleaya cordata extract contains sanguinaine and chelerythrine, which have fungicidal and insecticidal activity. Sanguinarine (pseudochelerythrine) is a potent inhibitor of NF-kappaB activation, IkappaBalpha phosphorylation, and degradation.Macleaya cordata contains several alkaloids including sanguinarine, chelerythrine, protopine, and allocryptopine.Our product, Macleaya cordata extract mainly constains with sanguinarine and chelerythrine. It was been show to be reversible inhibitors of the enzymatic hydrolysis of acetylthiocholine.
It was reported that a study was made of a possible inhibitory action on the enzymatic hydrolysis of acetylthiocholine by human erythrocyte acetylcholinesterase of principal alkaloids isolated from Chelidonium majusL. and Macleaya cordata and microcarpa,and of drugs Ukrain and Sanguirythrine. Among all examined agents berberine, sanguinarine and Sanguirythrine were the strongest inhibitors of this reaction.Judging from the data obtained, sanguinarine and chelerythrine exert similar inhibitory effects on the reaction of enzymatic hydrolysis of acetylthiocholine.
Application:
Feed antibiotics, Agriculture insecticide, Agriculture bactericide, Veterinary injection
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