Organic Vine tea Extract Dihydromyricetin CAS No.: 27200-12-0,China Kang price supplier

Dihydromyricetin

[Brief Chemical Information]

Other names:   Ampelopsin, ampeloptin           
Chemical name:  (2R,3R)-3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-4-one
Botanical origin:  Ampolopsis grossedentata W.T.Wang. 
Part of the plant used:  Stems and Leaves
Specifications:  Dihydromyricetin ( DMY ) 90%,95%,98% (HPLC) 
CAS No. : 27200-12--0 
Molecular structure & weight:  C15H12O8, 320.25 
Extract solvents:  Ethanol & water 
Appearance:  Fine white crystalline powder for the 98% above, the low content powder is light greenish white.
Solubility:  easy soluble in hot water, hot ethanol and acetone, soluble in ethanol, methanol, slightly soluble acetic ether, insoluble in chloroform, petroleum ether.
Stability:  stable in heat, but when heated to 100 °C above, it will be oxidized irreversibly. It is stable in acidity and neutral.

Solubility (25°C)	DMSO ≥64 mg/mL
	Water <1 mg/mL
	Ethanol ≥64 mg/mL
Storage	2 years-20°CPowder
	2 weeks4°Cin DMSO
	6 months-80°Cin DMSO

[Introduction of Dihydromyricetin]

Ampelopsis grossedentata also vine tea is called Teng Cha in China, as a Chinese Herbal Medicine it has a glycol flavor, the nature is cool; it can alleviate fevers, drunkness, cure rheumatism, strengthen physique, diuresis, and many other functions.

Ampelopsis grossedentata contains rich flavones, amino acids, vitamins; Proteins and essential trace element.

The flavones are mainly dihydromyricetin, myricetin, quercetin, quercetin-5-O-²–D-glucoside, taxifolin, apiin.

 

Some of flavonoids, for example Ampelopsin and Dihydromyricetin, are main active ingredients in vine tea, which have almost same MIC and MBC comparing with berberine, and have high Free radical scavenging activity varies between 73.3~91.5%. It can also reduce oxidative damage in the body, anti-aging, reduce the deformation and tissue necrosis of animal liver. Dihydromyricetin also have ability on lifting alcohol poisoning, prevent for AFL, Inhibit the deterioration of liver cells, decrease the incidence of liver cancer. In these case Dihydromyricetin is consider as a good product for enhance activity of SOD, protecting liver and removing inebriation. Dihydromyricetin now entered clinical trials as a class of new drugs when researcher of Dihydromyricetin achieved a major breakthrough in field of anti-leukemia and medicine of Nasopharyngeal cancer. Ampelopsis injection is expected to be a new treatment for leukemia and nasopharyngeal cancer.

 

Biological Activity

Dihydromyricetin (Ampelopsin (flavanol); Ampeloptin) is a natural antioxidant with good prospects. The physicochemical properties of dihydromyricetin (Ampelopsin (flavanol); Ampeloptin) were analyzed by ultraviolet–visible spectrometry, infrared spectrometry, scanning electron microscopy, differential scanning calorimetry, X-ray diffractometry. The result showed that dihydromyricetin (Ampelopsin (flavanol); Ampeloptin) and lecithin in the complex were combined by non-covalent bond, did not form a new compound and the solubility of dihydromyricetin in n-octanol was significantly enhanced. It was found that the dihydromyricetin–lecithin complex was an effective scavenger of DPPH radicals with an IC50 of 22.60 μg/mL. In the Rancimat antioxidant test using lard oil as substrate, the performance of the complex with protection factor of 6.67 was superior to that of butylated hydroxytoluene with protection factor of 5.54. [1]

 

Dihydromyricetin applications:
1.Clearing heat and dampness, Clear the free radical,Anti-oxidation
2.Repressing hyperactive of Liver and reduce blood pressure
3. Helps improving the taste and flavors of the poultry meat.

4.Protect liver, HELP recovery from drunkness.DHM supplements  greatly reduces hangover symptoms. Dosage range suggested for hangover 1-8mg/kg body weight, based on DHM 98%

[COA of Dihydromyricetin, Vine Tea Extract]

Analysis Item	Specification		Result
Physical tests:
Assay	98%	98.3%
Appearance	white powder	Conforms
Odor	Characteristic	Conforms
Taste	Characteristic	Conforms
Chemical tests:
Arsenic (As)	NMT 2ppm	Conforms
Cadmium(Cd)	NMT 1ppm	Conforms
Lead (Pb)	NMT 2ppm	Conforms
Heavy Metals	NMT 10ppm	Complies
Microbiological test
Total Plate Count	1000cfu/ml Max	Conforms
Salmonella	Absent	Absent
Yeast & Mold	100cfu/g Max	Conforms
E.Coli	Negative	Conforms

* COA showed in this file is just an example not the finished one

   

[Packing & Storage]

1KG : Packed in  Aluminum foil bag with pharma-grade polybags;

5KG : Packed in drum with pharma-grade polybag. Drum size:30*40CM Drum Weight:1.5KG

25KG: Packed in HDPE drums/ Hardboard cartons.with pharma-grade polybag.Carton size:D38 CM * H42CM Drum gross weight:2.8kgs

Store in a well-closed container Away from moisture.

 

[Shelf Life]

Two years if sealed and store away from direct sun light.

 

[About Manufacturer Kang Biotech]

History: “Hunan Kang Biotech” is a subsidiary of “Hunan Kang Pharmaceutical Group”, which engaged in the natural ingredients' research & development (R & D), production and selling. Providing the high-quality natural materials for manufacturers and enterprises of botanical drug, health food, beverage, cosmetic etc.

 

Certification: Our company is equipped with UV/HPLC/GC/AA and other modern analyzing instruments to assure high quality. Our factory have passed GMP in Aug.10.2010, Certificate No.:J0261

 

Factory: Hunan Kangbiotech’s factory covers an area of 130 Acres, and the production workshop is designed according to GMP standard.

 

[Why Chose Kang Biotech]

1)Free sample(10-20g or enough to detection) and Unconditional assume respons

2)100% Natural porduct, without any synthetize ingredient

3)Manufacturer direct supply, provide OEM, R&D service

4)GMPs,Gsp

5)Leading Plant Extract manufacturer in China