| ≥1 piece |
pomegranate Extract, Pomegranate Ellagic acid, Pomegranate Punicalagin A&B Punica granatum L.
Introduction:
pomegranate extract contain high ellagic acid, punicalagin A&B. The most abundant polyphenols in pomegranate are the hydrolyzable tannins called ellagitannins formed when ellagic acid binds with a carbohydrate. Punicalagins are tannins with free-radical scavenging properties in laboratory experiments and with potential human effects. Punicalagins are absorbed into the human body and may have dietary value as antioxidants, but conclusive proof of efficacy in humans has not yet been shown. During intestinal metabolism by bacteria, ellagitannins and punicalagins are converted to urolithins which have unknown biological activity in vivo.
Many food and dietary supplement makers use pomegranate phenolic extracts as ingredients in their products instead of the juice. One of these extracts is ellagic acid, which may become bioavailable only after parent molecule punicalagins are metabolized. However, ingested ellagic acid from Pomegranate Juice does not accumulate in the blood in significant quantities and is rapidly excreted.
Potential health benefitsIn preliminary laboratory research and clinical trials, pomegranate may be effective in reducing heart disease risk factors, including LDL oxidation, macrophage oxidative status, and foam cell formation. In an article published in the American Journal of Clinical Nutrition in 2000, researchers detailed an experiment in which healthy adult men and unhealthy mice consumed pomegranate juice daily. After two weeks, the healthy men experienced increased antioxidant levels, which resulted in a ninety percent drop in LDL cholestoral oxidation. In the mice, "oxidation of LDL by peritoneal macrophages was reduced by up to 90% after pomegranate juice consumption."
In a limited study of hypertensive patients, consumption of pomegranate juice for two weeks was shown to reduce systolic blood pressure by inhibiting serum angiotensin-converting enzyme. Juice consumption may also inhibit viral infections while pomegranate extracts have antibacterial effects against dental plaque.
Clinical trial rationale and activityMetabolites of pomegranate juice ellagitannins localize specifically in the prostate gland, colon, and intestinal tissues of mice, leading to clinical studies of pomegranate extracts for efficacy against several diseases.
Specification:
40% Ellagic acid, 40% Punicalagin A&B