Supply Mannitol powder Pharma application Tablet accessories,China Teng Chao price supplier

 

Supply Mannitol powder Pharma application Tablet accessories

 

 

  What is Mannitol?  

Mannitol is a white, crystalline organic compound with the formula (C6H8(OH)6).  This polyol is used as an osmotic diuretic agent and a weak renal vasodilator. It was originally isolated from the secretions of the flowering ash, called manna after their resemblance to the Biblical food, and is also referred to as mannite and manna sugar.  In plants, it is used to induce osmotic stress.   

 

Specifications of Mannitol

Specification CP2005 BP2007 USP30 Assay,% 98-102.0 98-102.0 96-101.5 Clarity&color Less than 1#turbidity fsol'n Less than 1#turbidity fsol'n — Acidity&alalinity ≤0.3ml(Acidity) ≤0.2ml(Acidity) ≤0.3ml ≤0.3ml(Alkalinity) — Chloride,% ≤0.003 ≤0.005 ≤0.007 Sulphate,% ≤0.01 ≤0.01 ≤0.01 Oxalate,% ≤0.02 — — Reduing sugar,% — ≤0.2 Nearly zero Loss on drying,% ≤0.5 ≤0.5 ≤0.3 Ignttion reside,% ≤0.1 ≤0.1(ASH) — Heavy metals(Pb),% ≤0.001 — — Arsenic(AS2O3),% ≤0.0002 — ≤0.0001 Melting point,°C 166-170 165-170 164-169 Specific optical rotation — +23-+25 +137-+145 Nickel,mg/kg — ≤0.0001 — Sorbitol — Conforms — Bacteria endotoxin — Conforms —

 

Applications of Mannitol:

1. Mannitol is used clinically in osmotherapy to reduce acutely raised intracranial pressure until more definitive treatment can be applied, e.g., after head trauma.

2. Mannitol can also be used as a facilitating agent for the transportation of pharmaceuticals directly into the brain. The arteries of the blood-brain barrier are much more selective than normal arteries.

3. Mannitol is commonly used in the circuit prime of a heart lung machine during cardiopulmonary bypass. The presence of mannitol preserves renal function during the times of low blood flow and pressure, while the patient is on bypass.

 

 

 

 

 

 

 

 

 

 

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