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vitamin k2 MK-4 cas 863-61-6,China onicon price supplier

vitamin k2 MK-4 cas 863-61-6
min.order / fob price
≥1 piece
OriginChina
Production Capacity
CategoryNutrition Supplements
Update Time2022-09-21
company profile
HANGZHOU ONICON CHEMICAL CO.LTD
China
Contact: Mr.KEN CHEUNG
Tel: +86-717-6307507
Number of Employees: 20 ~ 50
Business Type: Manufacture
product details
Origin:China
Brand:onicon

vitamin k2 cas 863-61-6 MK-4 CAS 863-61-6

vitamin k2 cas 863-61-6 MK-4

 

Assay(Dry basis,HPLC)
98.0% min
98.8%
Solubility
Easily soluble in n-hexane, soluble in ethanol,slightly soluble in methanol,almost insoluble in water
Complies
Clarity in Hexane
Clear and Yellow
Complies
Identification
Ethanol+Potassium Hydroxide
Ethanol+Sodium Hydrosulfite
Absorption in Isooctane
Absorbance Ratio A1/A2
 
Blue
Yellow
325nm~327nm
0.32-0.38
 
Complies
Complies
Complies
0.37
Melting Point
33-37
36.2degree
Heavy Metals
20ppm max
15ppm
Arsenic
2 ppm max
Complies
Menaquinone
Not appear royal purple
Not appear royal purple
Water
0.5% max
0.4%
Residue On Ignition
0.10% max
0.07%
Solvent residue
 
 
Ethanol
0.5% max
0.3%
Propanol
0.5% max
0.2%
Other Related Substances ratio
0.01% max
Complies
Appearance
Yellow crystals powder
Yellow crystals powder

Storage: Store at -0 degree temperature. Protect from moisture.
Vitamin K is found in plants as phylloquinone (vitamin K1) and in animals as menaquinone (vitamin K2). Vitamin K2 is the collective term for a group of vitamin K compounds called menaquinones. Vitamin K2 now refers to any of the series of vitamin K compounds having unsaturated side chains, which are found in animals and bacteria. Vitamin K2 is a lipid soluble vitamin that is normally produced in the gastrointestinal track by bacteria but is available in synthetic form. Vitamin K2 is found in chicken egg yolk, butter, cow liver, certain cheeses and fermented soybean products such as natto. Natto is by far the best food source for vitamin K2. This form of vitamin K is also produced by certain bacteria, including some of the bacteria that comprise the microflora of the intestine. The dietary contribution of vitamin K2 is much less than that of vitamin K1.

Vitamin K2 is essential for the carboxylation of glutamate residues in certain proteins, to give carboxyglutamate. This modification allows the protein to bind calcium, an essential event in the blood clotting cascade. Carboxylation of glutamate is also important in other proteins involved in the mobilization or transport of calcium. Vitamin K2 is more effective than vitamin K1 with respect to osteoclastogenesis likewise hypocholesterolemic effects and the ability to slow atherosclerotic progression have only been observed with vitamin K2. This may be due in part to the geranylgeranyl side chain of vitamin K2 which is thought to inhibit the mevalonate pathway, thus preventing the prenylation of growth factors required for osteoclast activation in much the same way as nitrogen-containing bisphosphonates.

Vitamin K2 is the most biologically active form of vitamin K. It is also the most beneficial for bone health maximization. Vitamin K2 (menadione) may improve a group of blood disorders known as myelodysplastic syndromes (MDS). Vitamin K2 (menatetrenone) can prevent fractures and sustains lumbar bone mineral density in osteoporosis. Vitamin K2, combined with vitamin D and calcium, has been used primarily as treatment or prevention of osteoporosis. Vitamin K2 and its derivatives induce apoptosis in leukemia cells and enhance the effect of all-trans retinoic acid.

  The special effects of VK2
Blood clotting. Vitamin K2 is essential for the carboxylation of glutamate residues in certain proteins, to give carboxyglutamate. This modification allows the protein to bind calcium, an essential event in the blood clotting cascade.

Atherosclerotic. This may be due in part to the geranylgeranyl side chain of vitamin K2 which is thought to inhibit the mevalonate pathway, thus preventing the prenylation of growth factors required for osteoclast activation in much the same way as nitrogen-containing bisphosphonates.

Bone health. Vitamin K2 (menatetrenone) can prevent fractures and sustains lumbar bone mineral density in osteoporosis.

Osteoporosis. Vitamin K2, combined with vitamin D and calcium, has been used primarily as treatment or prevention of osteoporosis.

Leucocythemia. Vitamin K2 and its derivatives induce apoptosis in leukemia cells and enhance the effef aof all-trans retinoic acid.

Blood disorders. Vitamin K2 (menadione) may improve a group of blood disorders known as myelodysplastic syndromes (MDS).

Vitamin K2 is more effective than vitamin K1 with respect to osteoclastogenesis likewise hypocholesterolemic effects and the ability to slow atherosclerotic progression have only been observed with vitamin K2.


 

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