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piperine is the alkaloid responsible for the pungency of black pepper and long pepper, along with chavicine (an isomer of piperine). It has also been used in some forms of traditional medicine and as an insecticide. piperine forms monoclinic needles, is slightly soluble in water and more so in alcohol, ether or chloroform: the solution in alcohol has a pepper-like taste.

 

Piperine has shown 'anti-depression like activity', and cognitive enhancing effects in rats.

 

Piperine has also been found to inhibit human CYP3A4 and P-glycoprotein, Enzymes important for the metabolism and transport of xenobiotics and metabolites. In animal studies, piperine also inhibited other enzymes important in drug metabolism. By inhibiting drug metabolism, piperine may increase the bioavailability of various compounds and alter the effectiveness of some medications. 

 

 

In February 2008, researchers discovered that piperine can stimulate pigmentation in the skin, together with the exposure to UVB light.