CAS: 331-39-5
Molecular formula: C9H8O4
Molecular weight: 180.16
English name: 3,4-dihydroxy-cinnamic acid
3,4-dihydroxybenzeneacrylic acid
3,4-dihydroxycinnamic acid
Nature description:
Pale Yellow powder.
Melting point 194-198 ° C (decomposition), softening at 194 ° C,
Soluble in hot water, ethanol, slightly soluble in cold water,
When the alkali solution turns orange,
E-type caffeic acid melting point 223-225 ° C (decomposition).
Caffeic acid has the general chemical properties of phenolic acids. Since the structure contains an unsaturated double bond, it is easily oxidized, especially in an alkaline solution, and its aqueous solution is greenish in the case of ferric chloride.
It is found in many traditional Chinese medicines, such as wild carrots (male cranes), sphagnum sylvestris, buckwheat, and Pinellia ternata. Some Chinese medicines do not contain caffeic acid, but contain the ester formed by caffeic acid, chlorogenic acid ( It is one of the antibacterial active ingredients of honeysuckle, in addition, ramie, mulberry, valerian and the like also contain chlorogenic acid), and chlorogenic acid is hydrolyzed to form caffeic acid.
Synthetic process: Caffeic acid is mainly prepared by chemical, biosynthesis, microwave chemical synthesis and the like.
Identification:
1. Color reaction of ferric chloride meets the requirements
2, caffeic acid should have maximum absorption at a wavelength of 323 nm, and caffeic acid has a minimum absorption at a wavelength of 261 nm. Compliance
3, aqueous solution of caffeic acid plus hydrochloric acid and sodium nitrite, plus sodium hydroxide is alkaline, red. Compliance
Quality Standard:
1 melting point 219-224 ° C
2 Chloride ≤0.01%
3 moisture ≤0.5%
4 heavy metals ≤0.0015%
5 burning residue ≤0.2%
6 infrared match
7 indicators ≥98.0% dry product
Chromatographic conditions: mobile phase: acetonitrile: 0.3% phosphoric acid solution (35:65) Detection wavelength: 320 nm (for reference only)
Uses: Caffeic acid contains unsaturated double bonds in the structure and is easily oxidized. It is especially unstable in alkaline solution. It has cardiovascular protection, anti-mutagenic, anti-cancer, anti-bacterial, anti-viral, lipid-lowering, hypoglycemic, anti-leukemia, Pharmacological effects such as immune regulation, choleretic hemostasis and anti-oxidation. Caffeic acid can shrink, strengthen microvessels, reduce permeability, improve blood coagulation function and white blood cell platelet count, have hemostasis effect, have better hemostasis effect on viscera, less toxicity, and are often used in various surgical and medical bleeding prevention. And treatment, has significant curative effect on gynecological hemorrhagic diseases, also used for chemotherapy and radiotherapy of tumor diseases and other causes of leukopenia thrombocytopenia, and has certain curative effects on diseases such as primary thrombocytopenia and reduction of aplastic leukopenia. Caffeic acid is an important pharmaceutical product, pharmaceutical intermediate and chemical raw material.
Important raw materials and intermediates for medicine. It has a wide range of bacteriostatic effects in medicine, but it can be inactivated by proteins in the body. In vitro tests showed that it had antiviral activity and had a strong inhibitory effect on vaccinia and adenovirus, followed by polio type I and parainfluenza type III viruses.
At a dose of 3 μg of caffeic acid, 20 μg of rattlesnake phosphatidyl phospholipase was completely inhibited and used as an antivenin.
Caffeic acid has a hemostatic effect, and has a better hemostatic effect on the internal organs and less toxicity. Caffeic acid tablets are a new type of hemostatic leukocyte drug, which has the function of contracting and strengthening microvessels, improving the function of blood coagulation factors, increasing white blood cells and platelets, and the indications are to prevent bleeding or hemostasis during surgery, as well as bleeding in internal medicine and obstetrics. Hemostasis of sexually transmitted diseases can also be used for leukopenia and thrombocytopenia caused by various causes.
Shelf life: two years