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Since the 1980s, biochemical and medical studies have demonstrated significant antioxidant properties of Grape Seed oligomeric proanthocyanidins. Together with tannins, polyphenols and polyunsaturated fatty acids, these seed constituents display inhibitory activities against several experimental disease models, including cancer, heart failure and other disorders of oxidative stress.

 

Grape seed oil from crushed seeds is used in cosmeceuticals and skincare products for many perceived health benefits. Grape Seed Oil has some amount of tocopherols (vitamin E), but is notable for its high contents of phytosterols, polyunsaturated fatty acids such as linoleic acid, oleic acid and alpha-linolenic acid.

 

Proanthocyanidins, refer to a larger class of polyphenols, called flavanols, in which occur OPCs (oligomeric proanthocyanidins), the simplest flavanols. More complex polyphenols, having the same polymeric building block, form the group of tannins. Flavanols are distinguished at the core molecule by the hydroxyl group as opposed to the ketone near same position on the pyran ring in the generally yellow class of flavonoids. Colorless OPCs are a strictly defined group of 3 flavanols naturally occurring as a mix of monomers, di-mers, and tri-mers of the catechin building block, which is a 4x-hydroxylation of the flavan-3-ol core.