| ≥1 piece |
Diosmin is a flavone, a member of the flavonoid family. Diosmin aglycone is diosmetin. It can be found in Teucrium gnaphalodes, a plant endemic to the Iberian Peninsula.
Diosmin is a semisynthetic flavonoid molecule derived from citrus d (modified hesperidin). It is an oral phlebotropic drug used in the treatment of venous disease, i.e., chronic venous insufficiency (CVI) including spider and varicose veins, leg swelling (edema), stasis dermatitis and venous ulcers. It is also used as a stand-alone or surgical adjunctive therapy in hemorrhoidal disease (HD)
Diosmin is a nutrient that is widely contained in citrus and that has been indicated to improve glucose metabolism in diabetic disorders. Recently, we demonstrated that diosmin induces β-endorphin to lower hyperglycemia in diabetic rats. However, the mechanisms of diosmin in opioid secretion were unclear. Therefore, we focused on the secretion of opioids from isolated adrenal glands induced by diosmin. The changes in the released β-endorphin-like immunoreactivity (BER) were determined using ELISA. Diosmin increased the BER level in a dose-dependent manner, and this effect was markedly reduced in the absence of calcium ions. Activation of the imidazoline I-2 receptor (I-2R) has been introduced to induce opioid secretion. Interestingly, we observed that diosmin activates CHO cells expressing I-R.
Additionally, diosmin-increased BER was inhibited by the blockade of I-2R in isolated adrenal glands. Additionally, an antagonist of I-2R blocked diosmin-induced effects, including the reduction in hyperglycemia and the increase in plasma BER in streptozotocin-induced diabetic rats (STZ-diabetic rats). Repeated treatment of STZ-diabetic rats with diosmin for one week induced changes in hepatic glycogen, lipid levels, and the expression of phosphoenolpyruvate carboxykinase (PEPCK). Furthermore, an antagonist of I-2R blocked the diosmin-induced changes. Additionally, plasma lipids modified by diosmin were also reversed by the blockade of I-2R in STZ-diabetic rats. Taken together, we suggest that diosmin may activate I-2R to enhance the secretion of β-endorphin from adrenal glands and to influence metabolic homeostasis, resulting in alleviation of blood glucose and lipids in STZ-diabetic rats.
Certificate of Analysis:
| Item | Specifications | Results |
| Assay (dry substance) | 90.0%~102.0% | 95.1% |
| Identification | The infrared absorption spectrophotometry of the product is same as the infraredabsorption spectrophotometry of Diosmin CRS. | Complies |
| Examine the chromatogram obtained in the assay. The principal peak in the chromatogram obtained with the test solution is similar in retention time and size to the principal peak in the chromatogram obtained with the reference solution(a) | Complies | |
| Iodine | ≤0.1% | Complies |
| Pyridine | ≤200ppm | 26ppm |
| Water(KF) | ≤6.0% | 3.42% |
| Sulphated Ash | ≤0.2% | 0.06% |
| Heavy metals | ≤20ppm | Complies |
| Related substances | ||
| Impurity A | ≤1.0% | 0.01% |
| Impurity B | ≤5.0% | 1.19% |
| Impurity C | ≤3.0% | 1.88% |
| Impurity E | ≤3.0% | 1.50% |
| Impurity F | ≤3.0% | 0.22% |
| Diosmetin-7-O-β-D glucoside(RRT=1.1) | ≤0.4% | 0.25% |
| Any other impurity | ≤1.0% | Complies |
| Total of other impurities and impurity A | ≤1.0% | 0.52% |
| Any unspecified impurities | ≤0.1% | <0.10% |
| Total | ≤10% | 5.31% |
| Microbial Limit | ||
| Total Plate count (CFU/g) | ≤1000 CFU/g | 40cfu/g |
| Yeasts & Molds (CFU/g) | ≤100 CFU/g | <10cfu/g |
| E. Coliform | Negative in 1g | Negative in 1g |
| Appearance | Greyish-yellow or light yellow hygroscopic powder. Practically insoluble in water,soluble in dimethyl sulfoxide, practically insoluble in alcohol.It dissolves in dilute solutions of alkali hydroxides | Complies |
Healthlife Biotechnology Co., Ltd. is a pharmaceutical company mainly engaged in export of products including, without limitation, pharmaceutical raw materials both for vet and human, also Vitamins, Amino Acids, minerals, peptides, plant extract, feed and food additives.
Q1: Can I get some samples?
A: Yes, free samples are available for most of our products, you only need to pay the shipping cost.
Q2: How to confirm the quality before orders?
A: Two ways, either by free samples, or send us the detailed specifications, we will arrange the production as per your requirement.
Q3: What's your MOQ?
A: Normally 1 kg, but smaller quantity is also acceptable for some special products.
Q4: What's the delivery lead time?
A: 2-5 days after payment.
Q5: How about discount?
A: Mainly based on quantity, also some promotional products with special discount from time to time.
Q6: How to contact us?
A: IM: Trademanager, Skype, Whatsapp, Wechat; Call us directly or send us email.