| ≥1 piece |
Product name: L-Lysine-S-Carboxy Methyl-L-Cysteine
Synonyme : L-Carbocysteine-Lysine, SCMC-Lys
CAS#: 49673-81-6
Molecular Formula: C 6 H 14 N 2 O 2 .C 5 H 9 NO 4 S
Specification:
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Item |
Specification |
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Description |
Ivory white or white powder |
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Specific rotation[α] D 20 |
-13.2°~ -15.2° |
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Assay |
98.0~101.5% |
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Impurity |
NMT 0.2% |
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Melting point |
|
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Moisture |
4.0~6.0% |
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IR |
Meet with the requirements |
Function:
Carbocysteine lysine salt monohydrate (SCMC-Lys) is a well-known mucoactive drug whose therapeutic efficacy is commonly related to the ability of SCMC-Lys to replace fucomucins by sialomucins. The aim of this study was to determine if SCMC-Lys couldexert an anti-oxidant action by scavenging reactive oxygen intermediates (ROIs). Our results show that SCMC-Lys proved effective as a selective scavenger of hypochlorous acid (HOCl) and hydroxyl radical (OH.), this effect being related to the reactivity of the SCMC tioether group. The scavenger activity of SCMC-Lys was observed in free cellular system as well as in activated human polymorphonuclear neutrophils (PMNs). SCMC-Lys scavenger activity on HOCl was paralleled by a powerful protection from HOCl-mediated inactivation ofalpha1-antitripsin (alpha1-AT) inhibitor, the main serum protease inhibitor. Production of interleukin-(IL-)8, a major mediator of PMN recruitment in inflammatory diseases, is known to be mediated by intracellular OH.SCMC-Lys significantly reduced IL-8 production on stimulated human peripheral blood mononuclear cells (PBMCs) in the same range of concentrations affecting OH. activity. It is concluded that SCMC-Lys could exert, in addition to its mucoactive capacity, an anti-oxidant action, thus contributing to the therapeutic efficacy of SCMC-Lys.