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Lithospermum erythrorhizon Extract Shikonin/Acetylshikonin,China Lyphar price supplier

Lithospermum erythrorhizon Extract Shikonin/Acetylshikonin
min.order / fob price
≥1 piece
OriginShaanxi China
Production Capacity1500 Kilogram/Kilograms per Month
CategoryPlant Extracts
Update Time2021-12-23
company profile
Xi'an Lyphar Biotech Co., Ltd.
China
Contact: Ms.Ms. Susan Hu
Tel: 0086-29-88891943
Number of Employees: 51 - 100 People
Business Type: Trading Company
product details
Model No:ly07-71
Origin:Shaanxi China
Brand:Lyphar

1 Shikonin/Acetylshikonin
2 Shikonin Powder
3 ISO Factory
4 Purple crystalline Powder
5 Have stock,manufacture

Lithospermum erythrorhizon Extract Shikonin/Acetylshikonin  

 

 

Product Name:

Shikonin

Appearance :

Purple crystalline Powder

CAS:

517-89-5

Molecular formula:

C16H16O5

M olecular weight :

288.2952

Supplier name:          

xi’an lyphar biotech co.,ltd

Synonyms

1,4-naphthalenedione,5,8-dihydroxy-2-(1-hydroxy-4-methyl-3-penten-1-yl)-; 5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)-1,4-naphthoquinone; 5,8-dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)naphthalene-1,4-dione; 5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methylpent-3-en-1-yl]naphthalene-1,4-dione

Specification :

98%

 

Structure

 

 

 

 

 

Introduction

 

Shikonin, a component of chinese herbal medicine, inhibits chemokine receptor function and suppresses human immunodeficiency virus type 1.

 

Function
 

Shikonin is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities, including inhibition of human immunodeficiency virus (HIV) type 1 (HIV-1). G Protein-coupled chemokine receptors are used by HIV-1 as coreceptors to enter the host cells. In this study, we assessed the effects of shikonin on chemokine receptor function and HIV-1 replication. The results showed that, at nanomolar concentrations, shikonin inhibited monocyte chemotaxis and calcium flux in response to a variety of CC chemokines (CCL2 [monocyte chemoattractant protein 1], CCL3 [macrophage inflammatory protein 1alpha], and CCL5 [regulated upon activation, normal T-cell expressed and secreted protein]), the CXC chemokine (CXCL12 [stromal cell-derived factor 1alpha]), and classic chemoattractants (formylmethionyl-leucine-phenylalanine and complement fraction C5a). Shikonin down-regulated surface expression of CCR5, a primary HIV-1 coreceptor, on macrophages to a greater degree than the other receptors (CCR1, CCR2, CXCR4, and the formyl peptide receptor) did. CCR5 mRNA expression was also down-regulated by the compound. Additionally, shikonin inhibited the replication of a multidrug-resistant strain and pediatric clinical isolates of HIV in human peripheral blood mononuclear cells, with 50% inhibitory concentrations (IC(50)s) ranging from 96 to 366 nM. Shikonin also effectively inhibited the replication of the HIV Ba-L isolate in monocytes/macrophages, with an IC(50) of 470 nM. Our results suggest that the anti-HIV and anti-inflammatory activities of shikonin may be related to its interference with chemokine receptor expression and function. Therefore, shikonin, as a naturally occurring, low-molecular-weight pan-chemokine receptor inhibitor, constitutes a basis for the development of novel anti-HIV therapeutic agents

 

 

[ Shelf Life ] 2 years
[ Storage ] Store in cool and dry places, keep away from light

[ Packing ] 25kg/fiber drum;Inner package:two double plastic bags.

 

 

 

 

 

 

 

 

  

 

 

 

 

 

 

Type:
Herbal Extract
Variety:
Lithosperraum erythrorhizon extract
Form:
Powder
Part:
Root
Extraction Type:
Solvent Extraction
Packaging:
Drum,Glass Container,Vacuum Packed, Aluninium foiled bag
Place of Origin:
Shaanxi China (Mainland)
Grade:
Pharmaceutical Grade
Brand Name:
Lyphar
Model Number:
ly07-71
Appearance:
Purple crystalline Powder
Latin Name:
Arnebia euchroma.
Specification Available:
3%-30%
CAS:
517-89-5
Molecular formula:
C16H16O5
Molecular weight:
288.2952
Refractive_index:
1.642
Flash Point(℃):
311°C
Boiling Point:
567.4°C at 760 mmHg
Density:
1.373g/cm3
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