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Melatonin biosynthesis by restricting the light cycle. The pineal gland in the control of optical nerve, from tryptophan into 5- hydroxytryptophane, further into 5- HT, N- acetyl transferase in the role, then into N- acetyl -5- serotonin, the synthesis of melatonin, the body's circadian rhythm changes of content. Nocturnal melatonin secretion than during the day 5 ~ 10 times, in the early morning 2:00 to 3:00 peak. Results the content of Hakola in saliva melatonin night shift workers, also confirmed that the circadian change. Melatonin biosynthesis also has a great relationship with age, it can be made of the placenta to the fetus, but also by the suckling awarded the newborn. Therefore, it can detect very small amounts of melatonin in newborn infants in vivo, secretion increased only until March, age, and presents the circadian rhythm is obvious, 3 ~ 5 years old children's nocturnal melatonin secretion was the highest, adolescent secretion decreased slightly, then increases with age and decreased gradually, to the final but lower than the youth childhood, to old age the circadian rhythm is becoming large and even disappeared.