Mulberry Leaf Extract 1-Deoxynojirimycin DNJ Natural White Mulberry,China Geneham price supplier

 

 

 

1-Deoxynojirimycin, hereinafter referred to as DNJ, is a powerful α-glucosidase inhibitors. After being absorbed by human body, it could inhibit the activity of invertase, maltose enzyme, α-glucosidase and α-amylase enzyme, reduce absorption of carbohydrate digestion and glucose, reduce blood sugar,and its hypoglycemic activity is better than sulfonylureas, and its side effects, such as hypoglycemia, is much more less than other hypoglycemic drugs, it also has a good safety; besides, this product has little influence on the normal eating. In addition, DNJ also has significant antiretroviral activity, it could inhibit tumor metastasis and be used as a carrier for the synthesis of high pure maltose .

 

  Specification Sheet of  1-Deoxynojirimycin    

ITEMS	SPECIFICATION
PHYSICAL TE STS
APPEARANCE	BROWN POWDER
ODOR	CHARACTERISTIC
COUNTRY OF ORIGIN	CHINA
PARTICLE SIZE	THROUGH 80 MESH
PLANT PART USED	LEAF
BULK DENSITY	0.4~0.6g/ml
SOLUBILITY	WATER SOLUBLE
CHEMICAL TESTS
ASSAY(HPLC)	1%, 1.5%, 2%, 10%, 20% ,30%
EXTRACT SOLVENTS	ETHANOL & WATER
CARRIERS USED	NONE
LOSS ON DRYING	≤5.0%
ASH	≤5.0%
HEAVY METALS(Pb)	≤5mg/kg
ARSENIC(As)	≤2mg/kg
MICROBIOLOGICAL TEST
TOTAL PLATE COUNT	≤1000CFU/G
YEASTS AND MOLDS	≤100 CFU/G
SALMONELLA	NEGATIVE
E.COLI	NEGATIVE

 

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1.     How does 1-deoxynojirimycin works ?

1-Deoxynojirimycin(DNJ) is a kind of alkaloid present in Mulberry leaves and root bark.DNJ is approved to have effects on lowering blood glucose, Antiviral activity and help to improve skin metabolism and purify skin.

Research shows that when DNJ entered the body, it can inhibit the decomposition of starch and sugar by sucrase, maltase, α-glucosidase, α-amylase enzyme, thus blocking the body's absorption of sugar, and inhibit the increase of glucose without diet change. In addition, DNJ can inhibit the glucose modification process of HIV membrane glycoprotein. Meanwhile, the accumulation of immature glycoproteins may inhibit the cell fusion and the binding between virus and host cell receptor, and the formation of cell body harmony to inhibit the the replication of MoLV so as to inhibit the viral activity.

 

2. What's the function of 1-deoxynojirimycin?

Mulberry Leaf is considered as a nice herb in the ancient China for anti-inflammation, anti-aging and maintaining health. Mulberry leaf is rich in amino acids,vitamin C and antioxidants. Among this components, the most valuable are Rutoside and DNJ(1-Deoxynojimycin),The latest Chinese research has shown Rutoside and DNJ are effective in regulating blood fat, balancing blood pressure, reducing blood glucose, and boosting metabolism. So they are widely used as raw materials for curing diabetes.

 

3.     What’s the effect of 1-Deoxynojirimycin on Blood Lipid Profiles in Humans?

Mulberry leaves are rich in 1-deoxynojirimycin (DNJ), an inhibitor of α-glucosidase. We previously showed that DNJ-rich mulberry leaf extract suppressed elevation of postprandial blood glucose in humans. The objective of this study was to evaluate the effects of DNJ-rich mulberry leaf extract on plasma lipid profiles in humans. An open-label, single-group study was conducted in 10 subjects with initial serum triglyceride (TG) level ≥200 mg/dl. Subjects ingested capsules containing DNJ-rich mulberry leaf extract at 12 mg three times daily before meals for 12 weeks. Our findings showed a modest decrease in serum TG level and beneficial changes in the lipoprotein profile following 12-week administration of DNJ-rich mulberry leaf extract. No significant changes in hematological or biochemical parameters were observed during the study period; no adverse events associated with DNJ-rich mulberry leaf extract occurred.

 

 

 

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1. A small amount of free samples;
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4. Full set of technical data, as CoA, MoA, MSDS, Process Flow, Test Reports, etc.
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