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natamycin (Pimaricin) is a polyene macrolide antibiotic produced by submerged aerobic fermentation of Streptomyces natalensis and related species,also known as Natamycine, Natamycina, Pimaricine, and Pimaricina. Fermentation is conducted for several days, and the antibiotic is isolated either by broth extraction or by extraction of the mycelium.it is an antifungal which can be used as antibiotic to treat most fungus infections. Natamycin is an natural antimicrobial food additive used to protect food from mold and yeast growth. Its application is reliable and safe to human body. Natamycin has been globally used in a variety of foods and beverages, eg. Cheese , Baked food , Meat , Jam, Jelly, Marinated food, Fish, Chicken, Surface treatment for semi-dried, cured meat products , Drinks , Juice , Wines , Yogurts , man-made butter, Miscellaneous.. Natamycin is deemed to be a GRAS (Generally Recognized as Safe) substance in USA , and is assigned to be the number E-235-natural preservative in European Union.