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nisin is a natural food preservative (bacteriocin), with high efficiency, high stability, safety, and without side effects. it is used in processed foods during production to extend shelf life by suppressing gram-positive spoilage and pathogenic bacteria. nisin was awarded the generally regarded as safe (gras) designation in the u.s. federal register and is approved as a natural food preservative in the u.s., the fao/who and the e.u.