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Product name : genistein
Botanical source: Sophora japonica L.
Specification : 98%
Appearance : White Fine powder
CAS NO. 446-72-0
Molecular formula : C15H10O5
Molecular weight : 270.24
Extract solvent : Ethanol
Heavy metals: <1ppm
GMO: Non-GMO
Irradiation: Non-Irradiation
Test method : HPLC
Application : Food supplements. Healthcare supplements
Standard : USP/EP Standard
Brief introduction of Genistein
Genistein Mainly exists in leguminosae, such as Huaijiao(Sophora japonica L.), greater content of roots and roots
An isoflavonoid derived from soy products. Shaanxi Creative herb biotechnology Co,.ltd can supply Genistein 98% from Sophora japonica L.
1 Genistein inhibits protein tyrosine kinases, including the EGF receptor kinase (IC50 = 2.6 µM). The inhibition is competitive with respect to ATP and non-competitive with respect to the phosphate acceptor.1,2 It has a trivial effect on the activity of PKA and PKC (IC50 > 350 µM).1,2 In addition, Genistein inhibits Topoisomerase II activity,3 cause cell cycle arrest and apoptosis in Jurkat T-leukemia cells.4 It down regulates the transcription of genes involved in angiogenesis,5,6 and inhibit the action of GABA on recombinant GABA-A receptors.7 Genistein also inhibits tumor cell proliferation and induces tumor cell differentiation. 8-10
How does genistein produce good effect to women ?
1. genistein with Anti-Osteoporsis
Italian researchers including Francesco Squadrito, MD, of Italy's University of Messina.
They studied 389 postmenopausal Italian women with osteopenia, in which bone mineral density is less than ideal but not as severe as osteoporosis
2.Genistein With anti-oxidation, with estrogen and anti-estrogen properties
GEN (genistein or genistein) and its aglycone are the highest content of soybean isoflavones,
The aglycone form of soybean isoflavone is more active than the glycoside form, especially the Genistein activity is more higher.With phytoestrogen bidirectional regulation. MCF-7 cells are ER positive human breast cancer cell lines, it Can specifically accept estrogen
or estrogen-like active substances to regulate and proliferate .Estrogen-like value-added is very sensitive, simple, it can distinguish between agonists and antagonists, So it is widely
used in the rapid screening and evaluation of phytoestrogens of environmental estrogens.