| ≥1 piece |
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Product:
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Pyridoxal Phosphate
Pyridoxal-5-phosphate
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Grade:
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Enterprise
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Lot :
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OF1807A
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Code:
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170701
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CAS No.:
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[54-47-7]
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Mol. Formula:
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C 8 H 10 NO 6 P
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Mol. Weight:
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247.14
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Packing:
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25 Kg / Drum
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Content
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99.0~101.0%
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99.6%
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Pyridoxine (HPLC)
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<0.5%
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<0.5%
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pH
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2.6~3.0
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2.8
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Loss on drying
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<10.0%
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3.1%
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Heavy metals
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≤20ppm
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<10ppm
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Total Plate Count
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≤ 1000cfu/g
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Complies
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yeast & Mold
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≤ 100cfu/g
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Complies
|
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E.Coil
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Negative
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Complies
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Salmonella
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Negative
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Complies
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Staphylococcus Aureus
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Negative
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Complies
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Appearance
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Off-white to light yellow powder
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Off-white to light yellow powder
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PLP acts as a coenzyme in all transamination reactions, and in some decarboxylation and deamination reactions of amino acids. The aldehyde group of PLP forms a Schiff-base linkage (internal aldimine) with the ε-amino group of a specific lysine group of the aminotransferase enzyme. The α-amino group of the amino acid substrate displaces the ε-amino group of the active-site lysine residue. The resulting external aldimine becomes deprotonated to become a quinoid intermediate, which in turn accepts a proton at a different position to become a ketimine. The resulting ketimine is hydrolysed so that the amino group remains on the complex [ 1 ] .
Additionally, PLP is used by aminotransferases (or transaminases) that act upon unusual sugars such as perosamine and desosamine [ 2 ] . In these reactions, the PLP reacts with glutamate, which transfers its alpha-amino group to PLP to make pyridoxamine phosphate (PMP). PMP then transfers its nitrogen to the sugar, making an amino sugar.
PLP is also involved in various beta-elimination reactions such as the reactions carried out by serine dehydratase and GDP-4-keto-6-deoxymannose-3-dehydratase (ColD) [ 2 ] .
It is also active in the condensation reaction in heme synthesis.
Pyridoxal phosphate is not required in the transaminase reaction of lysine catabolism.