Mainly reguarding 3, 5-dihydroxybenzoic as starting material,obtained through Methylation, restore , chlorinated, Wittig Horner reaction , or obtained through further demethylating, with haloacetic acids (or halogenated acetate)reacting in alkali action. This method is preparation easy and reproducibility good. These compounds or medicinal salts can inhibit microglia activation, which can be used for the treatment of Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis and other neurodegenerative diseases. R1 and R2 are H, methyl, ethyl and propyl, CH2COOH, CH2COOR (R-methyl, ethyl and propyl, alkyl); Ar contains various substituted benzene, aromatic heterocyclic base (such as pyridine, quinoline-based, furan-based, the terthiophene base, pyrrole base, etc.).
Acetyl-resveratrol
Acetyl-resveratrol is called prodrug on medicinal chemistry. Hydroxyls are replaced by acetyls. Acetyl-resveratrol is more stable than trans-resveratrol. When absorbed, it returns to resveratrol under action of metabolism.
Water soluble resveratrol
Resveratrol is Ester-solubility active ingredient which can be used as anti-aging, anti-oxidant. It has been proved that it is high safety. However its solubility in water is about 5mg/100ml.
Water solubility of water soluble Resveratrol in water is about 10-15mg/ml.
Water solubility of water soluble is 400 times that of Resveratrol. It can be widely used in non-alcoholic beverage and additive in food, health product and related industry.