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Hyaluronic acid (hyaluronic acid, HA) is a mucopolysaccharide a widely existing in nature, by [(1 → 3) - β -D- acetyl glucosamine - (1 → 4) - β -D- uronic acid disaccharide composed of repeating units]. HA is widely present in vertebrate connective tissue and body fluids, such as the synovial fluid, vitreous, umbilical cord, skin etc.. HA has a unique viscoelastic and water retention, good biocompatibility and non immunogenicity, and has the physiological function and biological role, so it is widely used in clinical. Balazs will classify some applied at present: viscoelastic operation (Viscosurgery), viscosupple mentation (Viscosupplementation), viscoelastic filling (Viscoaugmentation), viscoelastic barrier (Viscoseparation, namely, anti adhesion) and viscoelastic protection (Viscoprotection). In addition, HA has applications in drug delivery and tissue engineering and so On. HA can be used in food, cosmetics and medicine