Pharmacology Action: St. John's wort is now receiving much attention and is highly esteemed for its anti-depressive and sedative properties. It is an effective remedy for the nervous system, relaxing tension, and anxiety and lifting the spirits. St. John's wort has acquired an excellent reputation for use in cases of anxiety, depression, and unrest. It is thought that this might be brought about by the plant's ability to enhance the effect of neurotransmitters in the brain. As a tissue restorative for nerves, St. John's wort is indicated for stroke patients, for mild neuroses, sleepwalkers, and accident victims.