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Product Name: 10-hydroxycamptothecin
Synonym: Spyrano[3, 4: 6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione
Molecular Formula: C20H16N2O5
Formula Weight: 364.35
CAS No. 19685-09-7 ，7689-03-4
Botanical source: Camptotheca acuminata Decne
Appearance: Light Yellow Crystal Powder
Odor: Characteristic
Solubility: Insoluble in water, its sodium salt is the water-soluble, its organic solution has blue fluorescence.
Specification: 10-hydroxycamptothecin >98%
Sieve analysis: 100% through 80 mesh
Storage: Store in cool & dry place, Keep away from strong light and heat.
Shelf life: 24Months when properly stored.
Packing: Aluminum foil-bag and two plastic-bags inside
Functions:
10-hydroxycamptothecin is the derivative of camptothecine that is a micro-alkaloid from camptotheca Acuminate (a tree native to mainland China). Is a kind of pharmaceutical intermediate, an alkaloid originally isolated from the Camptotheca acuminata, exerted inhibitory effects on DNA topoisomerase (Topo )[1]and has anticancer activity in vitro and in vivo. It can also induce differentiation of leukemia MELC[2]and HL-60[3]cells. The purpose of this study is to investigate the proliferation-inhibiting and differentiation-inducing actions of HCPT on human hepatoma Hep G2 cells