| ≥1 piece |
Honeysuckle extract chlorogenic acid
jillcui(at)yahoo(dot)cn
Product Name: Honeysuckle Flower P. E.
CAS No.: 327-97-9
Molecular Formula: C16H18O9
Molecular Weight: 354.31
Plant origin
Chlorogenic acid is a phenolic natural product isolated from the leaves and fruits of dicotyledonous plants, including the coffee beanLythrum salicaria Dodonaea viscose (L. )Jacp. Polypodium vulgare L. Stachytarpheta jamaicensis(L. )VahlBrassica oleracea L. Var. Capitata L. Polygonum aviculare L. Galium verum L. And Sambucus javanica Reinw.
Main functions
1About pharmacodynamics study
It is investigated that chlorogenicacid has a poor absorption when taken by mouth with a little part of which absorbed in small intestine while most of it will be absorbed in the terms of benzoic acid acid exists in the form of metabolites in the blood plasma. Protein binding: It is proved by test in vitro that chlogogenic acid can bind with HAS in different concentration. There is only one combine site in low concentration. It appears to be several sites in high concentration in the region of HAS and IIA. Excretion: Chlogogenic acid and its metabolites in blood plasma mainly discharged through kidney but discharged along with urine when it taken by mouth. And benzene propanoic acid and cinnamic acid.
1) The protection to cardiovascular
A large number of experiments have show that Chlorogenic acid, as a kind of free radical scavenger and antioxidant, has a good protection to cardiovascular. Chang Cuiqing proved that chlorogenic acid has a preparatory prevention to the damage of endothelial cells induced by ox-LDL. Chlopcikova discovered that chlorogenic can protect Myocardium cell from being damaged by oxidant of Doxombiein, DOx and has a prominent inhibition of peroxidization of mitochondria envelope lipid induced by iron reserves dependence DOX. It goes to show chlorogenic acid can protect vascular endothelium cell by removing radical intermediate and antioxidant lipids and has a further prevention to arteriosclerosishypertension and thrombosis.
2) Anti-mutagens and anti-cancer
The experiment of animals shows that chlorogenic acid can prevent and inhibit colon cancer and stomach cancer. Jiang discovered chlorogenic acid brought bigger DNA fragments produced by tumor cells and its agglutination. Aryl hydrocarbon hydroxylase is an important Metabolizing Enzyme of polynuclear aromatic and its activeness would improve the mutagens of anti- polynuclear aromatic of tissue cells. Research in vitro discovered that chlorogenic acid can improve the activeness of Aryl hydrocarbon hydroxylase. It also can inhibit the formation of 8-OHdG and the grow of Escherichia foetidaStaphylococcus aureusblack hay bacillus and legionella.
3) Reduce blood fat
Veins have given chlorogenic the power of reducing cholesterol and triglycerides in the blood of rats. When adding chlorogenic acid to the food of rats, it discovered that the cholesterol in rats lungs and livers has also reduced.
4) Anti-leukemia
Chiang found that chlorogenic acid had light activeness of anti-leukemia by the experiment in vitro. J. Bandyopadhyay has proved that chlorogenic acid can inhibit Ber-Abl and c-Abl and induce the dead of the original lymphocytosis in the body of leukemia patients.
5) Adjust the immune function
The research in vitro has showed chlorogenic acid can obviously strengthen T cells caused by influenza as well as induce humans lymphocytes and albumen cells to produce 7-IFN and α -IFN. It can improve the lgG1 and Ll4 level of rats. In a recent research, it is discovered that chlorogenic acid has the ability to activate nerve cardiac troponin to strengthen the function of macrophages.
6) Lower glucose
It is proved by the research of Andrade-Cetto and Wiedenfeld H that
Chlorogenic acid has potential function in lowering glucose in animals body. The function may have relationships with the inhibiting of glucose-6- and the absorption of glucose. 0