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Centella asiatica (CA) is a very important medicinal herb used in the orient, which is also becoming popular in the West. Commonly known as mandukparni or Indian pennywort or jalbrahmi, it has been used as a medicine in the Ayurvedic tradition of India for thousands of years and listed in the historic ‘Sushruta Samhita’, an ancient Indian medical text. The herb is also used by the people of Java and other Indonesian islands. In China, known as gotu kola, it is one of the reported “miracle elixirs of life” known over 2000 years ago. Centella asiatica or gotu kola should not be confused with kola nut as it does not contain any caffeine and has not been shown to have stimulant properties. In the nineteenth century, Centella asiatica and its extracts were incorporated into the Indian pharmacopoeia, wherein in addition to wound healing, it was recommended for the treatment of various skin conditions such as leprosy, lupus, varicose ulcers, eczema, psoriasis, diarrhoea, fever, amenorrhea, and diseases of the female genitourinary tract.
The primary active constituents of centella asiatica are saponins (also called triterpenoids), which include asiaticosides, in which a trisaccharide moiety is linked to the aglycone asiatic acid, madecassoside and madasiatic acid. These triterpene saponins and their sapogenins are mainly responsible for the wound healing and vascular effects by inhibiting the production of collagen at the wound site. Other components isolated from CA, such as brahmoside and brahminoside, may be responsible for CNS and uterorelaxant actions, but are yet to be confirmed by clinical studies. Crude extract containing glycosides isothankuniside and thankuniside showed antifertility action in mice. Centelloside and its derivatives are found to be effective in the treatment of venous hypertension. In addition, the total extract contains plant sterols, flavonoids, and other components with no known pharmacological activity, namely, abundant tannins (20-25%), essential acid (0.1% with beta-chariophylen, trans-beta-pharnesen and germachrene D), phytosterols (campesterol, sitosterol, stigmasterol), mucilages, resins, free aminoacids (alanine, serine, aminobutyrate, aspartate, glutamate, lysine and treonine), flavonoids (derivates of chercetin and kempferol), an alkaloid (hydrochotine), a bitter component (vallerine), fatty acids (linoleic acids, linolnelic, oleic, palmitic and stearic acids).
10%, 20%, 30%, 40%, 50%, 60%, 90% HPLC
(Asiaticoside, asiatic acid, madecassic acid)
40%, 70%, 95% HPLC
-Wound healing:
The centella asiatica extracts (CAE) have been used traditionally for wound healing and the research has been increasingly supportive for these claims.
-Venous insufficiency:
One of primary effects of centella asiatica extract was postulated to be on connective tissues by strengthening the weakened veins
Centella asiatica was described to possess CNS effects in Indian literature such as stimulatory-nervine tonic, rejuvenant, sedative, tranquilizer and intelligence promoting property.
-Antidepressant properties:
The antidepressant effects of total triterpenes from centella asiatica extract on the immobility time in forced swimming mice and concentration of amino acid in mice brain tissue was observed.
-Antiepileptic properties:
Asian centella asiatica extract increases the cerebral levels of GABA, which explains its traditional use as anxiolytic and anticonvulsant.
-Cognitive and antioxidant properties:
Centella asiatica is known to re-vitalize the brain and nervous system, increase attention span and concentration and combat aging.
-Gastric ulcer:
A laboratory study was reported in which aqueous extract of centella asiatica was found to be effective in inhibiting gastric lesions induced by ethanol administration.
-Antinociceptive and antiinflammatory properties:
The effects of centella asiatica upon pain (antinociception) and inflammation in rodent models were reported.
-Radioprotection:
Previous studies have suggested that CA could be useful in preventing radiation-induced behavioural changes during clinical radiotherapy.
-Miscellaneous uses:
A study reported the intracellular activities of an aqueous centella asiatica extract against herpes simplex viruses, in vitro, containing both anti HSV-1 and antiHSV-2 activities.
Healthlife Biotechnology Co., Ltd. is a pharmaceutical company mainly engaged in export of products including, without limitation, pharmaceutical raw materials both for vet and human, also Vitamins, Amino Acids, minerals, peptides, plant extract, feed and food additives.
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A: Yes, free samples are available for most of our products, you only need to pay the shipping cost.
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Q3: What's your MOQ?
A: Normally 1 kg, but smaller quantity is also acceptable for some special products.
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